The Ltd Edition ES-355 body is constructed of 5-layer laminated maple. The solid hard maple 24.75" SlimTaper 1960s "D" profile neck features an ebony fingerboard with a 12" radius and a 1.68" nut width. The neck has classic pearloid "Block" inlays and a vintage-style pearloid "Split Diamond" headstock design. To top off the vintage styling, Epiphone has included a "Tortoise" style pickguard with multi-binding. Tuning stability is assured with gold Grover 14:1 ratio machine heads, a gold Epiphone LockTone Tune-o-matic bridge and a gold Bigsby Tremolo. The volume and tone knobs, one for each pickup, are Black Speed with pointers for easy reference while on stage.

The Ltd Edition ES-355 incorporates Alnico Classic humbuckers in the neck and bridge position. Patterned after the original Gibson '57 Classics, the Alnico Classic pickups use Alnico-V magnets with enamel wire to give you a tone that is warm and subtle with full, even response that will still give you that classic humbucker overdrive when you need it. The 3-way Epiphone Toggle/pickup selector switch is a deep, aged vintage yellow and is wired for the standard configuration with position one controlling the neck pickup's volume and tone while position two controls the bridge pickup's volume and tone.

The Ltd. Edition ES-355's unique tonal range was the result of its groundbreaking design. A wood block runs through the center of the body so the pickups are mounted much the same way as in a solid body guitar allowing for two hollow chambered areas over the violin style f -holes and in the double cutaway wings.