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Detailed Product Description
Recombinant Human Growth Hormone for Injection
[NAME OF THE MEDICINAL PRODUCT]
Generic Name: Recombinant Human Growth Hormone
Trade Name: KIGTROPIN
[INGREDIENTS]
Recombinant Human Growth Hormone and excipients.
Molecular Formula: C990H1528N262O300S7 with 191 amino acids residues.
Molecular Weight: 22125D
Origin of the Active Ingredient: KIGTROPIN is a Recombinants Human Growth Hormone. KIGTROPIN is produced by recombinant DNA technology in E.coli secretion expression system. KIGTROPIN has the same amino acid sequence with 191 residues as the native human growth hormone produced in the human body..
[CHARACTERS]
White Lyophilized powder.
[INDICATION]
Growth failure of children due to endogenous growth hormone deficiency (GHD).
In adults with growth hormone deficiency, KIGTROPIN reduces fat mass, increases muscle mass and improves energy, vitality and subjective well-being. In patients suffering from severe burns, AIDS associated muscle wasting, or undergoing major operations, KIGTROPIN promotes wound healing, attenuates the protein-catabolic response and improves whole-body nitrogen condition after operation.
[SPECIFICATIONS]
10IU/3.7mg/1.0ml/vial
[DOSAGE AND ADMINISTRATION]
Before administration, add 1ml of sterile water for injection to the rhGH vial of Lyophilized powder along the wall slowly. Shake it gently to fully dissolve the powder to get clarified solution. DO NOT shake violently.
For anti-aging, general health & healing, fat mobilization, a dose of 2-3 IU's per day will be sufficient for the majority. A dose of 1.5 to 2.0 IU's is considered to be a full replacement dose for those in their middle-age and beyond.
For gaining lean muscle and substantially improving body composition, a dose of 4-8 IUs per day will be necessary. Most people will respond very well at a dose of 4-5 IU's per day. For maximum benefit in this regard, the addition of Testosterone, Insulin, and low-dose t3 would be something to seriously consider. More on this in our comparative cycle guide of HGH/Insulin/IGF.
The recommended dosage for injection is 0.1-0.15IU/kg/day, inject before sleeping daily at the same time and the injection site should be changes frequently to prevent lipoatrophy at the site, or follow the physician's advice.
[ADVERSE REACTIONS]
Growth hormone may induce transient hyperglycosemia, which usually recover to normal level over time or after drug discontinuation.
About 1% children with microsomia in the clinical trial presented side effects, which usually presented transient reactions at the injection site (pain, tingling numbness, red swelling, etc) and the symptoms of fluid retention (peripheral edema, arthralgia or myalgia).These side effects usually appear at early stage and the incidence rate decreases over time which rarely affects daily activities.
Long-term injection of recombinant human growth hormone results in antibody production in minority people, however, the affinity of the antibody is low without exact clinical significance, The antibody may be induced if the anticipant effect of growth is not achieved, which may affect the efficacy if the affinity is over 2 mg/L.
[CONTRAINDICATIONS]
Children with closure of epiphysis are forbidden.
Patients with the progressive symptoms of tumor are forbidden.
Critical ill patients in acute shock stage of serious systematic infection are forbidden.
[STORAGE]
Keep at 2-8 Degrees Celsius in the refrigerator, away from light.
Before reconstitution:
--If refrigerated between 2-8 Degrees Celsius, it's good until expiration date.
--At room temperature (under 37oC) it's good for over 30 days.
After reconstitution:
--Use Bacteriostatic Water to reconstitute and keep in 2-8oC, it will be good for 20 days.
--Use Sterile Water to reconstitute and keep in 2-8oC. it will be good for 72 hours.
[PACKAGE]
Tube-shaped antibiotics glass bottle, 10 bottles/inner box.
[SHELF LIFE]
Two years.
[EXECUTIVE STANDARD]
Pharmacopoeia of People's Republic of China 2005 Edition 2
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