Anemia is the most common disorder of the blood.deficient in hemoglobin.  Either of these conditions can cause a lack of oxygen to be delivered to all parts of the body.  Resulting in symptoms such as; fatigue, cold hands, loss of appetite, pallor and weakness.  Severe anemia can weaken the immune system, cause poor co-ordination and mental fuzziness and impair wound healing.Causes of anemia include excessive blood loss, excessive destruction of red blood cells or deficient production of red blood cells.Excessive blood loss may be acute; as in a trauma situation, or chronic; as in heavy menstrual flow or a bleeding ulcer.Excessive destruction of red blood cells may occur when red blood cells have an abnormal shape nand other hereditary diseases and in vitamin and mineral deficiencies.Deficient production of red blood cells is the most common category of anemia, and poor nutrition is the most common cause.  The most frequent types of nutrient deficient anemia are those related to a deficiency of iron, folic acid, copper or vitamin B12.Iron deficiency anemia is most often seen in infants younger than two years old, teenage girls, pregnant women and the elderly.This type of anemia include factors associated with poor dietary intake of iron, an increased need for iron, reduced iron absorption, blood loss or a combination of these situations.

By altering the process conditions, acetic anhydride may also be produced on the same plant. Because both methanol and carbon monoxide are commodity raw materials, methanol carbonylation long appeared to be an attractive method for acetic acid production. Henry Drefyus at British Celanese developed a methanol carbonylation pilot plant as early as 1925. However, a lack of practical materials that could contain the corrosive reaction mixture at the high pressures needed (200 atm or more) discouraged commercialization of these routes. The first commercial methanol carbonylation process, which used a cobalt catalyst, was developed by German chemical company BASF in 1963. In 1968, a rhodium-based catalyst was discovered that could operate efficiently at lower pressure with almost no by-products. The first plant using this catalyst was built by US chemical company Monsanto Company in 1970, and rhodium-catalysed methanol carbonylation became the dominant method of acetic acid production (see Monsanto process). In the late 1990s, the chemicals company BP Chemicals commercialized the Cativa catalyst, which is promoted by ruthenium. This iridium-catalysed Cativa process is greener and more efficient and has largely supplanted the Monsanto process, often in the same production plants.