Detailed Product Description

Product Name : Camptothecin      

Assay : 98%-99%(HPLC)

Specific optical rotation : +3132°

Appearence : Off-white to light yellow powder

Loss on drying : <0.5%

Ash Content: <1%

What is Camptothecin :

Camptothecin is a plant secondary metabolite used as an anti-cancer drug that damages DNA, leading to the destruction of the cell. It comes from Camptotheca acuminata, a deciduous tree found in southern China. A close analogue, 9-methoxycamptothecin, is also present in the same source

Mechanism of Action:

Camptothecin affects the activity of the enzyme topoisomerase I, whose normal action is to cleave, unwind, and religate DNA. When camptothecin binds to topoisomerase I, it will be able to cleave but not to religate DNA. Thereby, camptothecin causes single strand breaks in DNA

CAS#: 7689-03-4

Molecular formula: C20H16N2O4

Molecular weight: 348.36